Optimizing Aggregated N-Of-1 Trial Designs for Predictive Biomarker Validation: Statistical Methods and Theoretical Findings

Optimizing Aggregated N-Of-1 Trial Designs for Predictive Biomarker Validation: Statistical Methods and Theoretical Findings

Background and Significance: Parallel-group randomized controlled trials (PG-RCTs) are the gold standard for detecting differences in mean improvement across treatment conditions. However, PG-RCTs provide limited information about individuals, making them poorly optimized for quantifying the relatio...

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Bibliographic Details
Main Authors: Rebecca C. Hendrickson, Ronald G. Thomas, Nicholas J. Schork, Murray A. Raskind
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Digital Health
Subjects:
N-of-1 trials
crossover trials
posttraumatic stress disorder (PTSD)
prazosin
biomarkers
personalized medicine
Online Access:https://www.frontiersin.org/article/10.3389/fdgth.2020.00013/full

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https://www.frontiersin.org/article/10.3389/fdgth.2020.00013/full

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