Treatment With Methotrexate Associated With Lipid Core Nanoparticles Prevents Aortic Dilation in a Murine Model of Marfan Syndrome

Treatment With Methotrexate Associated With Lipid Core Nanoparticles Prevents Aortic Dilation in a Murine Model of Marfan Syndrome

In Marfan syndrome (MFS), dilation, dissection, and rupture of the aorta occur. Inflammation can be involved in the pathogenicity of aortic defects and can thus be a therapeutic target for MFS. Previously, we showed that the formulation of methotrexate (MTX) associated with lipid nanoparticles (LDE)...

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Bibliographic Details
Main Authors: Maria Carolina Guido, Natalia de Menezes Lopes, Camila Inagaki Albuquerque, Elaine Rufo Tavares, Leonardo Jensen, Priscila de Oliveira Carvalho, Thauany Martins Tavoni, Ricardo Ribeiro Dias, Lygia da Veiga Pereira, Francisco Rafael Martins Laurindo, Raul Cavalcante Maranhão
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Marfan syndrome
lipid nanoparticle
inflammation
aortic dilation
adenosine
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.893774/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.893774/full

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