The role of rhIGF-1/BP3 in the prevention of pulmonary hypertension in bronchopulmonary dysplasia and its underlying mechanism

Abstract Background This study aimed to determine whether postnatal treatment with recombinant human IGF-1 (rhIGF-1)/binding peptide 3 (BP3) ameliorates lung injury and prevents pulmonary hypertension (PH) in bronchopulmonary dysplasia (BPD) models. Methods We used two models of BPD in this study: o...

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Bibliographic Details
Main Authors: Sehua Qu, Lianqiang Shan, Xin Chen, Zhen Zhang, Yumeng Wu, Yun Chen, Feixiang Zhuo, Yitong Wang, Huaifu Dong
Format: Article
Language:English
Published: BMC 2023-06-01
Series:BMC Pulmonary Medicine
Subjects:
Online Access:https://doi.org/10.1186/s12890-023-02498-1