Crystal structure of N-{N-[N-acetyl-(S)-leucyl]-(S)-leucyl}norleucinal (ALLN), an inhibitor of proteasome

Crystal structure of N-{N-[N-acetyl-(S)-leucyl]-(S)-leucyl}norleucinal (ALLN), an inhibitor of proteasome

The title compound, C20H37N3O4, also known by the acronym ALLN, is a tripeptidic inhibitor of the proteolytic activity of the proteasomes, enzyme complexes implicated in several neurodegenerative diseases and other disorders, including cancer. The crystal structure of ALLN, solved from synchrotron r...

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Bibliographic Details
Main Authors: Andrzej Czerwinski, Channa Basava, Miroslawa Dauter, Zbigniew Dauter
Format: Article
Language:English
Published: International Union of Crystallography 2015-03-01
Series:Acta Crystallographica Section E: Crystallographic Communications
Subjects:
crystal structure
proteasome inhibitor
hydrogen bonding
antiparallel β-sheet.
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2056989015002091

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http://scripts.iucr.org/cgi-bin/paper?S2056989015002091

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