Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts

Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts

Sphingosine 1-phosphate (S1P) is an extra- and intracellular mediator that regulates cell growth, survival, migration, and adhesion in many cell types. S1P lyase is the enzyme that irreversibly cleaves S1P and thereby constitutes the ultimate step in sphingolipid catabolism. It has been reported pre...

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Bibliographic Details
Main Authors: Katja Ihlefeld, Hans Vienken, Ralf Frederik Claas, Kira Blankenbach, Agnes Rudowski, Michael ter Braak, Alexander Koch, Paul P. Van Veldhoven, Josef Pfeilschifter, Dagmar Meyer zu Heringdorf
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Journal of Lipid Research
Subjects:
sphingolipids
lysophospholipid
apoptosis
fluorescence microscopy
transport
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520356406

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http://www.sciencedirect.com/science/article/pii/S0022227520356406

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