The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway
Alternative splicing of pre-mRNA increases transcriptome and proteome diversity by generating distinct isoforms that encode functionally diverse proteins, thus affecting many biological processes, including innate immunity. cGAS-STING signaling pathway, whose key molecules also undergo alternative s...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.771744/full |
| _version_ | 1818402047930662912 |
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| author | Jiaqian Liang Ze Hong Boyue Sun Zhaoxi Guo Chen Wang Juanjuan Zhu |
| author_facet | Jiaqian Liang Ze Hong Boyue Sun Zhaoxi Guo Chen Wang Juanjuan Zhu |
| author_sort | Jiaqian Liang |
| collection | DOAJ |
| description | Alternative splicing of pre-mRNA increases transcriptome and proteome diversity by generating distinct isoforms that encode functionally diverse proteins, thus affecting many biological processes, including innate immunity. cGAS-STING signaling pathway, whose key molecules also undergo alternative splicing, plays a crucial role in regulating innate immunity. Protein isoforms of key components in the cGAS-STING-TBK1-IRF3 axis have been detected in a variety of species. A chain of evidence showed that these protein isoforms exhibit distinct functions compared to their normal counterparts. The mentioned isoforms act as positive or negative modulators in interferon response via distinct mechanisms. Particularly, we highlight that alternative splicing serves a vital function for the host to avoid the overactivation of the cGAS-STING signaling pathway and that viruses can utilize alternative splicing to resist antiviral response by the host. These findings could provide insights for potential alternative splicing-targeting therapeutic applications. |
| first_indexed | 2024-12-14T08:02:09Z |
| format | Article |
| id | doaj.art-f071fe819167418abe923d324ea88c9c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T08:02:09Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f071fe819167418abe923d324ea88c9c2022-12-21T23:10:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-11-011210.3389/fimmu.2021.771744771744The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling PathwayJiaqian Liang0Ze Hong1Boyue Sun2Zhaoxi Guo3Chen Wang4Juanjuan Zhu5State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, ChinaState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, ChinaDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, IsraelState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, ChinaState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, ChinaState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, ChinaAlternative splicing of pre-mRNA increases transcriptome and proteome diversity by generating distinct isoforms that encode functionally diverse proteins, thus affecting many biological processes, including innate immunity. cGAS-STING signaling pathway, whose key molecules also undergo alternative splicing, plays a crucial role in regulating innate immunity. Protein isoforms of key components in the cGAS-STING-TBK1-IRF3 axis have been detected in a variety of species. A chain of evidence showed that these protein isoforms exhibit distinct functions compared to their normal counterparts. The mentioned isoforms act as positive or negative modulators in interferon response via distinct mechanisms. Particularly, we highlight that alternative splicing serves a vital function for the host to avoid the overactivation of the cGAS-STING signaling pathway and that viruses can utilize alternative splicing to resist antiviral response by the host. These findings could provide insights for potential alternative splicing-targeting therapeutic applications.https://www.frontiersin.org/articles/10.3389/fimmu.2021.771744/fullalternative splicingspliced isoformscGAS-STING signaling pathwayIFN responseantiviral response |
| spellingShingle | Jiaqian Liang Ze Hong Boyue Sun Zhaoxi Guo Chen Wang Juanjuan Zhu The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway Frontiers in Immunology alternative splicing spliced isoforms cGAS-STING signaling pathway IFN response antiviral response |
| title | The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway |
| title_full | The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway |
| title_fullStr | The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway |
| title_full_unstemmed | The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway |
| title_short | The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway |
| title_sort | alternatively spliced isoforms of key molecules in the cgas sting signaling pathway |
| topic | alternative splicing spliced isoforms cGAS-STING signaling pathway IFN response antiviral response |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.771744/full |
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