Genetic and Structural Variation in the O-Antigen of Salmonella enterica Serovar Typhimurium Isolates Causing Bloodstream Infections in the Democratic Republic of the Congo

Genetic and Structural Variation in the O-Antigen of Salmonella enterica Serovar Typhimurium Isolates Causing Bloodstream Infections in the Democratic Republic of the Congo

ABSTRACT Salmonella enterica serovar Typhimurium causes a devastating burden of invasive disease in sub-Saharan Africa with high levels of antimicrobial resistance. No licensed vaccine is available, but O-antigen-based candidates are in development, as the O-antigen moiety of lipopolysaccharides is...

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Bibliographic Details
Main Authors: Sandra Van Puyvelde, Gianmarco Gasperini, Michael Biggel, Marie-France Phoba, Maria Michelina Raso, Tessa de Block, Leen N. Vanheer, Stijn Deborggraeve, Olivier Vandenberg, Nicholas Thomson, Neil Ravenscroft, Calman A. Maclennan, Barbara Bellich, Paola Cescutti, Gordon Dougan, Jan Jacobs, Octavie Lunguya, Francesca Micoli
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
Democratic Republic of the Congo
O-antigen
Salmonella Typhimurium
genomics
iNTS
surface structures
Online Access:https://journals.asm.org/doi/10.1128/mbio.00374-22

Internet

https://journals.asm.org/doi/10.1128/mbio.00374-22

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