Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

Cancer survivors suffer from progressive frailty, multimorbidity, and premature morbidity. We hypothesise that therapy-induced senescence and senescence progression via bystander effects are significant causes of this premature ageing phenotype. Accordingly, the study addresses the question whether...

Full description

Bibliographic Details
Main Authors: Edward Fielder, Tengfei Wan, Ghazaleh Alimohammadiha, Abbas Ishaq, Evon Low, B Melanie Weigand, George Kelly, Craig Parker, Brigid Griffin, Diana Jurk, Viktor I Korolchuk, Thomas von Zglinicki, Satomi Miwa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
ageing
senescence
senolytic
metformin
frailty
Online Access:https://elifesciences.org/articles/75492

Internet

https://elifesciences.org/articles/75492

Similar Items