Evolution of specific RNA aptamers via SELEX targeting recombinant human CD36 protein: A candidate therapeutic target in severe malaria

Evolution of specific RNA aptamers via SELEX targeting recombinant human CD36 protein: A candidate therapeutic target in severe malaria

Objective: To isolate and characterize RNA aptamers that are specific to human CD36 protein using systematic evolution of ligands by exponential enrichment (SELEX) technology to identify candidates for adjunct therapy to reverse the binding of Plasmodium-infected erythrocytes. Methods: RNA aptamers...

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Bibliographic Details
Main Authors: Nik Abdul Aziz Nik Kamarudin, Judy Nur Aisha Sat, Nur Fatihah Mohd Zaidi, Khairul Mohd Fadzli Mustaffa
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Asian Pacific Journal of Tropical Biomedicine
Subjects:
rna aptamers; selex; cd36 protein; severe malaria; adjunct therapy; cytoadherence
Online Access:http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=1;spage=23;epage=32;aulast=Nik

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http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=1;spage=23;epage=32;aulast=Nik

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