Nature-inspired peptide of MtDef4 C-terminus tail enables protein delivery in mammalian cells

Nature-inspired peptide of MtDef4 C-terminus tail enables protein delivery in mammalian cells

Abstract Cell-penetrating peptides show promise as versatile tools for intracellular delivery of therapeutic agents. Various peptides have originated from natural proteins with antimicrobial activity. We investigated the mammalian cell-penetrating properties of a 16-residue peptide with the sequence...

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Bibliographic Details
Main Authors: Lucia Adriana Lifshits, Yoav Breuer, Marina Sova, Sumit Gupta, Dar Kadosh, Evgeny Weinberg, Zvi Hayouka, Daniel Z. Bar, Maayan Gal
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
Cell-penetrating peptide (CPP)
Cellular uptake
Delivery agents
Peptides
Protein transduction
MtDef4
Online Access:https://doi.org/10.1038/s41598-024-55274-4

Internet

https://doi.org/10.1038/s41598-024-55274-4

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