Intact proviruses are enriched in the colon and associated with PD-1+TIGIT− mucosal CD4+ T cells of people with HIV-1 on antiretroviral therapyResearch in context

Intact proviruses are enriched in the colon and associated with PD-1+TIGIT− mucosal CD4+ T cells of people with HIV-1 on antiretroviral therapyResearch in context

Summary: Background: The persistence of intact replication-competent HIV-1 proviruses is responsible for the virological rebound off treatment. The gut could be a major reservoir of HIV-1 due to the high number of infected target cells. Methods: We collected blood samples and intestinal biopsies (d...

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Bibliographic Details
Main Authors: Camille Vellas, Manon Nayrac, Nived Collercandy, Mary Requena, Nicolas Jeanne, Justine Latour, Chloé Dimeglio, Michelle Cazabat, Karl Barange, Laurent Alric, Nicolas Carrere, Guillaume Martin-Blondel, Jacques Izopet, Pierre Delobel
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:EBioMedicine
Subjects:
HIV reservoir
Gut
Intact and defective proviruses
CD4+ memory T cells
PD-1
TIGIT
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423005200

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http://www.sciencedirect.com/science/article/pii/S2352396423005200

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