Clonally expanded cytotoxic CD4+ T cells and the pathogenesis of IgG4-related disease

Clonally expanded cytotoxic CD4+ T cells and the pathogenesis of IgG4-related disease

IgG4-related disease (IgG4-RD) is a systemic condition of unknown cause characterized by highly fibrotic lesions, with dense lymphoplasmacytic infiltrates containing a preponderance of IgG4-expressing plasma cells. CD4+ T cells and B cells constitute the major inflammatory cell populations in IgG4-R...

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Bibliographic Details
Main Authors: Hamid Mattoo, John H. Stone, Shiv Pillai
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Autoimmunity
Subjects:
igg4-rd
cd4+ ctl
fibrosis
lymphoplasmacytic infiltrate
Online Access:http://dx.doi.org/10.1080/08916934.2017.1280029

Internet

http://dx.doi.org/10.1080/08916934.2017.1280029

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