A First for Human Vaccinology: GMP Compliant Radiation Attenuation of Plasmodium falciparum Sporozoites for Production of a Vaccine Against Malaria

A First for Human Vaccinology: GMP Compliant Radiation Attenuation of Plasmodium falciparum Sporozoites for Production of a Vaccine Against Malaria

Ionizing radiation (UV, X-ray and ɣ) administered at an appropriate dose to pathogenic organisms can prevent replication while preserving metabolic activity. We have established the GMP process for attenuation by ionizing radiation of the Plasmodium falciparum (Pf) sporozoites (SPZ) in Sanaria® PfSP...

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Bibliographic Details
Main Authors: Eric R. James, Steve Matheny, James Overby, B. Kim Lee Sim, Abraham G. Eappen, Tao Li, Ming Lin Li, Thomas L. Richie, Sumana Chakravarty, Anusha Gunasekera, Tooba Murshedkar, Peter F. Billingsley, Stephen L. Hoffman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
radiation
attenuation
malaria
sporozoite
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.851028/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.851028/full

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