A Dynamic Transcription Factor Signature Along the Colorectal Adenoma-Carcinoma Sequence in Patients With Co-Occurrent Adenoma and Carcinoma

A Dynamic Transcription Factor Signature Along the Colorectal Adenoma-Carcinoma Sequence in Patients With Co-Occurrent Adenoma and Carcinoma

BackgroundColorectal carcinoma (CRC) often arises from benign adenoma after a stepwise accumulation of genetic alterations. Here, we profiled the dynamic landscapes of transcription factors (TFs) in the mucosa-adenoma-carcinoma progression sequence.MethodsThe transcriptome data of co-occurrent adeno...

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Bibliographic Details
Main Authors: Zongfu Pan, Ying He, Wenjuan Zhu, Tong Xu, Xiaoping Hu, Ping Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
transcription factors
colorectal adenoma-carcinoma sequence
bioinformatics
tissue array
dynamic signature
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.597447/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.597447/full

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