Increased Susceptibility of the CD57<sup>−</sup> NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response

Increased Susceptibility of the CD57<sup>−</sup> NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response

Nowadays, the use of genetically modified NK cells is a promising strategy for cancer immunotherapy. The additional insertion of genes capable of inducing cell suicide allows for the timely elimination of the modified NK cells. Different subsets of the heterogenic NK cell population may differ in pr...

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Bibliographic Details
Main Authors: Anastasia I. Palamarchuk, Nadezhda A. Alekseeva, Maria A. Streltsova, Maria O. Ustiuzhanina, Polina A. Kobyzeva, Sofya A. Kust, Maria V. Grechikhina, Anna A. Boyko, Olga A. Shustova, Alexander M. Sapozhnikov, Elena I. Kovalenko
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
NK cells
genetic modifications
adoptive NK cells
HLA-DR
proliferation
retroviral vectors
Online Access:https://www.mdpi.com/1422-0067/22/24/13326

Internet

https://www.mdpi.com/1422-0067/22/24/13326

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