Monozygotic Twins Concordant for Common Variable Immunodeficiency: Strikingly Similar Clinical and Immune Profile Associated With a Polygenic Burden

Monozygotic Twins Concordant for Common Variable Immunodeficiency: Strikingly Similar Clinical and Immune Profile Associated With a Polygenic Burden

Monozygotic twins provide a unique opportunity to better understand complex genetic diseases and the relative contribution of heritable factors in shaping the immune system throughout life. Common Variable Immunodeficiency Disorders (CVID) are primary antibody defects displaying wide phenotypic and...

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Bibliographic Details
Main Authors: Susana L. Silva, Mariana Fonseca, Marcelo L. M. Pereira, Sara P. Silva, Rita R. Barbosa, Ana Serra-Caetano, Elena Blanco, Pedro Rosmaninho, Martin Pérez-Andrés, Ana Berta Sousa, Alexandre A. S. F. Raposo, Margarida Gama-Carvalho, Rui M. M. Victorino, Lennart Hammarstrom, Ana E. Sousa
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
CVID
flow-cytometry
polygenic disease
genetics
WES
monozygotic twins
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02503/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02503/full

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