Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3

Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3

Neutrophil extracellular trap (NET) formation requires chromatin decondensation before nuclear swelling and eventual extracellular release of DNA, which occurs together with nuclear and cytoplasmic antimicrobial proteins. A key mediator of chromatin decondensation is protein deiminase 4 (PAD4), whic...

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Bibliographic Details
Main Authors: Heather L. Clark, Serena Abbondante, Martin S. Minns, Elyse N. Greenberg, Yan Sun, Eric Pearlman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
Aspergillus
neutrophil extracellular trap
protein deiminase 4
CR3
keratitis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01182/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01182/full

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