CAR‐Aptamers Enable Traceless Enrichment and Monitoring of CAR‐Positive Cells and Overcome Tumor Immune Escape

CAR‐Aptamers Enable Traceless Enrichment and Monitoring of CAR‐Positive Cells and Overcome Tumor Immune Escape

Abstract Chimeric antigen receptor (CAR)‐positive cell therapy, specifically with anti‐CD19 CAR‐T (CAR19‐T) cells, achieves a high complete response during tumor treatment for hematological malignancies. Large‐scale production and application of CAR‐T therapy can be achieved by developing efficient...

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Bibliographic Details
Main Authors: Hang Zhou, Tuersunayi Abudureheman, Wei‐Wei Zheng, Li‐Ting Yang, Jian‐Min Zhu, Ai‐Bin Liang, Cai‐Wen Duan, Kaiming Chen
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Advanced Science
Subjects:
aptamers
CAR‐T cells
monitor
retargeting
traceless enrichment
Online Access:https://doi.org/10.1002/advs.202305566

Internet

https://doi.org/10.1002/advs.202305566

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