Cardioprotective Effect of Tangeretin by Inhibiting PTEN/AKT/mTOR Axis in Experimental Sepsis-Induced Myocardial Dysfunction

Cardioprotective Effect of Tangeretin by Inhibiting PTEN/AKT/mTOR Axis in Experimental Sepsis-Induced Myocardial Dysfunction

Sepsis aggregates undesirable immune response causing depression of ventricular myocardium and diastolic dysfunction. This present study examined the effect of a plant-derived flavone tangeretin (TG) on autophagy and reduction in myocardial dysfunction. The sepsis was induced by cecum ligation and p...

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Bibliographic Details
Main Authors: Predeepkumar Narayanappa Shiroorkar, Obaid Afzal, Imran Kazmi, Fahad A. Al-Abbasi, Abdulmalik Saleh Alfawaz Altamimi, Kumar Shiva Gubbiyappa, Nagaraja Sreeharsha
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
cecum ligation
puncture
tangeretin
sepsis
PTEN
AKT
Online Access:https://www.mdpi.com/1420-3049/25/23/5622

Internet

https://www.mdpi.com/1420-3049/25/23/5622

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