T-Cell Responses to Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses to the Colorectal Cancer Antigen, Guanylyl Cyclase C

T-Cell Responses to Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses to the Colorectal Cancer Antigen, Guanylyl Cyclase C

The Gram-positive bacterium Listeria monocytogenes (Lm) is an emerging platform for cancer immunotherapy. To date, over 30 clinical trials have been initiated testing Lm cancer vaccines across a wide variety of cancers, including lung, cervical, colorectal, and pancreatic. Here, we assessed the immu...

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Bibliographic Details
Main Authors: John C. Flickinger, Jagmohan Singh, Yanki Yarman, Robert D. Carlson, Joshua R. Barton, Scott A. Waldman, Adam E. Snook
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
listeria
vaccine
immunodominance
colorectal cancer
GUCY2C
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.855759/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.855759/full

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