Kinase Activity of PAR1b, Which Mediates Nuclear Translocation of the BRCA1 Tumor Suppressor, Is Potentiated by Nucleic Acid-Mediated PAR1b Multimerization

Kinase Activity of PAR1b, Which Mediates Nuclear Translocation of the BRCA1 Tumor Suppressor, Is Potentiated by Nucleic Acid-Mediated PAR1b Multimerization

PAR1b is a cytoplasmic serine/threonine kinase that controls cell polarity and cell–cell interaction by regulating microtubule stability while mediating cytoplasmic-to-nuclear translocation of BRCA1. PAR1b is also a cellular target of the CagA protein of <i>Helicobacter pylori,</i> which...

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Bibliographic Details
Main Authors: Hiroko Nishikawa, Priscillia Christiany, Takeru Hayashi, Hisashi Iizasa, Hironori Yoshiyama, Masanori Hatakeyama
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
PAR1b
multimerization
nucleic acids
kinase activation
EBER
gastric cancer
Online Access:https://www.mdpi.com/1422-0067/23/12/6634

Internet

https://www.mdpi.com/1422-0067/23/12/6634

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