A novel phage carrying capsule depolymerase effectively relieves pneumonia caused by multidrug-resistant Klebsiella aerogenes

A novel phage carrying capsule depolymerase effectively relieves pneumonia caused by multidrug-resistant Klebsiella aerogenes

Abstract Background Klebsiella aerogenes can cause ventilator-associated pneumonia by forming biofilms, and it is frequently associated with multidrug resistance. Phages are good antibiotic alternatives with unique advantages. There has been a lack of phage therapeutic explorations, kinetic studies,...

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Bibliographic Details
Main Authors: Xiaohu Cui, Bing Du, Junxia Feng, Yanling Feng, Zheng Fan, Jinfeng Chen, Jinghua Cui, Lin Gan, Tongtong Fu, Ziyan Tian, Rui Zhang, Chao Yan, Hanqing Zhao, Wenjian Xu, Ziying Xu, Zihui Yu, Zanbo Ding, Zhoufei Li, Yujie Chen, Guanhua Xue, Jing Yuan
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Biomedical Science
Subjects:
Klebsiella aerogenes
Pneumonia
Bacteriophage therapy
Depolymerase
Biofilms
Online Access:https://doi.org/10.1186/s12929-023-00946-y

Internet

https://doi.org/10.1186/s12929-023-00946-y

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