Targeting of the NOX1/ADAM17 Enzymatic Complex Regulates Soluble MCAM-Dependent Pro-Tumorigenic Activity in Colorectal Cancer

Targeting of the NOX1/ADAM17 Enzymatic Complex Regulates Soluble MCAM-Dependent Pro-Tumorigenic Activity in Colorectal Cancer

The melanoma cell adhesion molecule, shed from endothelial and cancer cells, is a soluble growth factor that induces tumor angiogenesis and growth. However, the molecular mechanism accounting for its generation in a tumor context is still unclear. To investigate this mechanism, we performed in vitro...

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Bibliographic Details
Main Authors: Jimmy Stalin, Oriana Coquoz, Rachel Jeitziner Marcone, Stephane Jemelin, Nina Desboeufs, Mauro Delorenzi, Marcel Blot-Chabaud, Beat A. Imhof, Curzio Ruegg
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Biomedicines
Subjects:
NADPH oxidases
melanoma cell adhesion molecule
angiogenesis
lymphangiogenesis
pharmacologic inhibitors
colorectal tumor
Online Access:https://www.mdpi.com/2227-9059/11/12/3185

Internet

https://www.mdpi.com/2227-9059/11/12/3185

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