Binding determinants in the interplay between porcine aminopeptidase N and enterotoxigenic Escherichia coli F4 fimbriae

Abstract The binding of F4+ enterotoxigenic Escherichia coli (ETEC) and the specific receptor on porcine intestinal epithelial cells is the initial step in F4+ ETEC infection. Porcine aminopeptidase N (APN) is a newly discovered receptor for F4 fimbriae that binds directly to FaeG adhesin, which is...

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Bibliographic Details
Main Authors: Pengpeng Xia, Guomei Quan, Yi Yang, Jing Zhao, Yiting Wang, Mingxu Zhou, Philip R. Hardwidge, Jianzhong Zhu, Siguo Liu, Guoqiang Zhu
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Veterinary Research
Online Access:http://link.springer.com/article/10.1186/s13567-018-0519-9