The Mitochondrial Calcium Uniporter Controls Skeletal Muscle Trophism In Vivo

The Mitochondrial Calcium Uniporter Controls Skeletal Muscle Trophism In Vivo

Muscle atrophy contributes to the poor prognosis of many pathophysiological conditions, but pharmacological therapies are still limited. Muscle activity leads to major swings in mitochondrial [Ca2+], which control aerobic metabolism, cell death, and survival pathways. We investigated in vivo the eff...

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Bibliographic Details
Main Authors: Cristina Mammucari, Gaia Gherardi, Ilaria Zamparo, Anna Raffaello, Simona Boncompagni, Francesco Chemello, Stefano Cagnin, Alessandra Braga, Sofia Zanin, Giorgia Pallafacchina, Lorena Zentilin, Marco Sandri, Diego De Stefani, Feliciano Protasi, Gerolamo Lanfranchi, Rosario Rizzuto
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715000984

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http://www.sciencedirect.com/science/article/pii/S2211124715000984

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