Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation

Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation

Pancreatic cancers driven by KRAS mutations require additional mutations for tumor progression. The tumor suppressor FBXW7 is altered in pancreatic cancers, but its contribution to pancreatic tumorigenesis is unknown. To determine potential cooperation between Kras mutation and Fbxw7 inactivation in...

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Bibliographic Details
Main Authors: Qiang Zhang, Yaqing Zhang, Joshua D. Parsels, Ines Lohse, Theodore S. Lawrence, Marina Pasca di Magliano, Yi Sun, Meredith A. Morgan
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558616301464

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http://www.sciencedirect.com/science/article/pii/S1476558616301464

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