CaV2.1 channel mutations causing familial hemiplegic migraine type 1 increase the susceptibility for cortical spreading depolarizations and seizures and worsen outcome after experimental traumatic brain injury

CaV2.1 channel mutations causing familial hemiplegic migraine type 1 increase the susceptibility for cortical spreading depolarizations and seizures and worsen outcome after experimental traumatic brain injury

Patients suffering from familial hemiplegic migraine type 1 (FHM1) may have a disproportionally severe outcome after head trauma, but the underlying mechanisms are unclear. Hence, we subjected knock-in mice carrying the severer S218L or milder R192Q FHM1 gain-of-function missense mutation in the CAC...

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Bibliographic Details
Main Authors: Nicole A Terpolilli, Reinhard Dolp, Kai Waehner, Susanne M Schwarzmaier, Elisabeth Rumbler, Boyan Todorov, Michel D Ferrari, Arn MJM van den Maagdenberg, Nikolaus Plesnila
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
traumatic brain injury
migraine
edema
cortical spreading depolarization
Online Access:https://elifesciences.org/articles/74923

Internet

https://elifesciences.org/articles/74923

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