The Impact of Intestinal Microbiota and Toll-like Receptor 2 Signaling on α-Synuclein Pathology in Nontransgenic Mice Injected with α-Synuclein Preformed Fibrils

The Impact of Intestinal Microbiota and Toll-like Receptor 2 Signaling on α-Synuclein Pathology in Nontransgenic Mice Injected with α-Synuclein Preformed Fibrils

Intestinal microbiota and Toll-like receptor 2 (TLR2), which can bind lipoteichoic acid produced by microbiota, might contribute to the pathogenesis of Parkinson’s disease (PD), which is characterized by α-synuclein accumulation. Although the contribution of intestinal microbiota and TLR2 to PD path...

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Bibliographic Details
Main Authors: Yukako Koyanagi, Momoe Kassai, Hiroshi Yoneyama
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Microorganisms
Subjects:
intestinal microbiota
Toll-like receptor 2
Parkinson’s disease
animal model
α-synuclein
Online Access:https://www.mdpi.com/2076-2607/12/1/106

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https://www.mdpi.com/2076-2607/12/1/106

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