A selective CB2R agonist (JWH133) protects against pulmonary fibrosis through inhibiting FAK/ERK/S100A4 signaling pathways

A selective CB2R agonist (JWH133) protects against pulmonary fibrosis through inhibiting FAK/ERK/S100A4 signaling pathways

Abstract Background The combination of the endocannabinoid system (ECS) and the type 2 cannabinoid receptor (CB2R) can activate various signal pathways, leading to distinct pathophysiological roles. This interaction has gained significant attention in recent research on fibrosis diseases. Focal adhe...

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Bibliographic Details
Main Authors: Xiao Wu, Lina Chen, Yiju Cheng, Yuquan Zhang, Wenting Yang, Lin Pan, Chenkun Fu, Honglan Zhu, Menglin Zhang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Pulmonary Medicine
Subjects:
Pulmonary fibrosis
Bleomycin
Cannabinoid receptor type 2
JWH133
Online Access:https://doi.org/10.1186/s12890-023-02747-3

Internet

https://doi.org/10.1186/s12890-023-02747-3

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