Identification of the decumbenone biosynthetic gene cluster in Penicillium decumbens and the importance for production of calbistrin

Identification of the decumbenone biosynthetic gene cluster in Penicillium decumbens and the importance for production of calbistrin

Abstract Background Filamentous fungi are important producers of secondary metabolites, low molecular weight molecules that often have bioactive properties. Calbistrin A is a secondary metabolite with an interesting structure that was recently found to have bioactivity against leukemia cells. It con...

Full description

Bibliographic Details
Main Authors: Sietske Grijseels, Carsten Pohl, Jens Christian Nielsen, Zahida Wasil, Yvonne Nygård, Jens Nielsen, Jens C. Frisvad, Kristian Fog Nielsen, Mhairi Workman, Thomas Ostenfeld Larsen, Arnold J. M. Driessen, Rasmus John Normand Frandsen
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Fungal Biology and Biotechnology
Subjects:
Penicillium decumbens
Calbistrin
Secondary metabolite
Decalin
Polyketide
Biosynthesis
Online Access:http://link.springer.com/article/10.1186/s40694-018-0063-4

Internet

http://link.springer.com/article/10.1186/s40694-018-0063-4

Similar Items