Role of the Fatty Acid Binding Proteins in Cardiovascular Diseases: A Systematic Review

Cardiovascular diseases (CVD) remain a global pandemic and leading cause of deaths worldwide. While several guidelines have been developed to control the development of CVDs, its prevalence keeps on increasing until this day. Cardiovascular risk factors, such as reduced exercises and high fat or glu...

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Main Authors: Hien C. Nguyen, Mohammad Qadura, Krishna K. Singh
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/9/11/3390
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author Hien C. Nguyen
Mohammad Qadura
Krishna K. Singh
author_facet Hien C. Nguyen
Mohammad Qadura
Krishna K. Singh
author_sort Hien C. Nguyen
collection DOAJ
description Cardiovascular diseases (CVD) remain a global pandemic and leading cause of deaths worldwide. While several guidelines have been developed to control the development of CVDs, its prevalence keeps on increasing until this day. Cardiovascular risk factors, such as reduced exercises and high fat or glucose diets, culminate in the development of the metabolic syndrome and eventually atherosclerosis, which is driven by high blood lipid and cholesterol levels, and by endothelial dysfunction. Late complications of atherosclerosis give rise to serious clinical cardiovascular manifestations such as myocardial infarction and hypertension. Therefore, endothelial functions and the lipid metabolism play critical roles in the pathogenesis of CVDs. Fatty acid-binding proteins are a family of intracellular proteins expressed in many cell types known mainly for their interaction with and trafficking of cellular lipids. The roles of a number of isoforms in this family have been implicated in lipid metabolic homeostasis, but their influence on endothelial function and vascular homeostasis remain largely unknown. This review’s purpose is to update fundamentals about the connection between cardiovascular disease, metabolism, endothelial function, and mainly the roles of fatty acid-binding proteins.
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spelling doaj.art-f0be1f37700d4103a3042e6d5a5635fa2023-11-20T18:11:13ZengMDPI AGJournal of Clinical Medicine2077-03832020-10-01911339010.3390/jcm9113390Role of the Fatty Acid Binding Proteins in Cardiovascular Diseases: A Systematic ReviewHien C. Nguyen0Mohammad Qadura1Krishna K. Singh2Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, CanadaVascular Surgery, Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, ON M5B 1W8, CanadaDepartment of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, CanadaCardiovascular diseases (CVD) remain a global pandemic and leading cause of deaths worldwide. While several guidelines have been developed to control the development of CVDs, its prevalence keeps on increasing until this day. Cardiovascular risk factors, such as reduced exercises and high fat or glucose diets, culminate in the development of the metabolic syndrome and eventually atherosclerosis, which is driven by high blood lipid and cholesterol levels, and by endothelial dysfunction. Late complications of atherosclerosis give rise to serious clinical cardiovascular manifestations such as myocardial infarction and hypertension. Therefore, endothelial functions and the lipid metabolism play critical roles in the pathogenesis of CVDs. Fatty acid-binding proteins are a family of intracellular proteins expressed in many cell types known mainly for their interaction with and trafficking of cellular lipids. The roles of a number of isoforms in this family have been implicated in lipid metabolic homeostasis, but their influence on endothelial function and vascular homeostasis remain largely unknown. This review’s purpose is to update fundamentals about the connection between cardiovascular disease, metabolism, endothelial function, and mainly the roles of fatty acid-binding proteins.https://www.mdpi.com/2077-0383/9/11/3390fatty acid binding proteinFABPcardiovascular diseaseheart failureperipheral artery diseaseatherosclerosis
spellingShingle Hien C. Nguyen
Mohammad Qadura
Krishna K. Singh
Role of the Fatty Acid Binding Proteins in Cardiovascular Diseases: A Systematic Review
Journal of Clinical Medicine
fatty acid binding protein
FABP
cardiovascular disease
heart failure
peripheral artery disease
atherosclerosis
title Role of the Fatty Acid Binding Proteins in Cardiovascular Diseases: A Systematic Review
title_full Role of the Fatty Acid Binding Proteins in Cardiovascular Diseases: A Systematic Review
title_fullStr Role of the Fatty Acid Binding Proteins in Cardiovascular Diseases: A Systematic Review
title_full_unstemmed Role of the Fatty Acid Binding Proteins in Cardiovascular Diseases: A Systematic Review
title_short Role of the Fatty Acid Binding Proteins in Cardiovascular Diseases: A Systematic Review
title_sort role of the fatty acid binding proteins in cardiovascular diseases a systematic review
topic fatty acid binding protein
FABP
cardiovascular disease
heart failure
peripheral artery disease
atherosclerosis
url https://www.mdpi.com/2077-0383/9/11/3390
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