Study on release characteristics of tinidazole-chitosan-sodium alginate complex membrane(替硝唑-壳聚糖-海藻酸钠生物复合膜的缓释性能研究)
系统研究了各种因素对复合膜的药物控释、稳定性、药物包埋率等性能的影响.最佳制备条件:pH=5.0、壳聚糖溶液质量分数为0.25%、海藻酸钠溶液质量分数为0.25%、海藻酸钠与壳聚糖的质量比为1:1.当壳聚糖溶液pH = 5.0时,复合膜的药物控释性能最强.通过Ca2+的交联,使替硝唑的包埋率达到96.1%.复合膜的溶胀度研究表明,在pH = 11的介质中具有最大的溶胀度....
Main Authors: | , , |
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Format: | Article |
Language: | zho |
Published: |
Zhejiang University Press
2006-07-01
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Series: | Zhejiang Daxue xuebao. Lixue ban |
Subjects: | |
Online Access: | https://doi.org/zjup/1008-9497.2006.33.4.444-446 |