Study on release characteristics of tinidazole-chitosan-sodium alginate complex membrane(替硝唑-壳聚糖-海藻酸钠生物复合膜的缓释性能研究)
系统研究了各种因素对复合膜的药物控释、稳定性、药物包埋率等性能的影响.最佳制备条件：pH=5.0、壳聚糖溶液质量分数为0.25%、海藻酸钠溶液质量分数为0.25%、海藻酸钠与壳聚糖的质量比为1：1.当壳聚糖溶液pH = 5.0时，复合膜的药物控释性能最强.通过Ca2+的交联，使替硝唑的包埋率达到96.1%.复合膜的溶胀度研究表明，在pH = 11的介质中具有最大的溶胀度....
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| Format: | Article |
| Language: | zho |
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Zhejiang University Press
2006-07-01
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| Series: | Zhejiang Daxue xuebao. Lixue ban |
| Subjects: | |
| Online Access: | https://doi.org/zjup/1008-9497.2006.33.4.444-446 |
| _version_ | 1797236315160313856 |
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| author | LINXian-zhen(林咸真) ZHENGHao(郑豪) ZHUKe-long(朱克龙) |
| author_facet | LINXian-zhen(林咸真) ZHENGHao(郑豪) ZHUKe-long(朱克龙) |
| author_sort | LINXian-zhen(林咸真) |
| collection | DOAJ |
| description | 系统研究了各种因素对复合膜的药物控释、稳定性、药物包埋率等性能的影响.最佳制备条件：pH=5.0、壳聚糖溶液质量分数为0.25%、海藻酸钠溶液质量分数为0.25%、海藻酸钠与壳聚糖的质量比为1：1.当壳聚糖溶液pH = 5.0时，复合膜的药物控释性能最强.通过Ca2+的交联，使替硝唑的包埋率达到96.1%.复合膜的溶胀度研究表明，在pH = 11的介质中具有最大的溶胀度. |
| first_indexed | 2024-04-24T17:01:54Z |
| format | Article |
| id | doaj.art-f0bec2a9915e44ada4bd4e2f37fffacb |
| institution | Directory Open Access Journal |
| issn | 1008-9497 |
| language | zho |
| last_indexed | 2024-04-24T17:01:54Z |
| publishDate | 2006-07-01 |
| publisher | Zhejiang University Press |
| record_format | Article |
| series | Zhejiang Daxue xuebao. Lixue ban |
| spelling | doaj.art-f0bec2a9915e44ada4bd4e2f37fffacb2024-03-29T01:58:23ZzhoZhejiang University PressZhejiang Daxue xuebao. Lixue ban1008-94972006-07-01334444446zjup/1008-9497.2006.33.4.444-446Study on release characteristics of tinidazole-chitosan-sodium alginate complex membrane(替硝唑-壳聚糖-海藻酸钠生物复合膜的缓释性能研究)LINXian-zhen(林咸真)0ZHENGHao(郑豪)1ZHUKe-long(朱克龙)2Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)系统研究了各种因素对复合膜的药物控释、稳定性、药物包埋率等性能的影响.最佳制备条件：pH=5.0、壳聚糖溶液质量分数为0.25%、海藻酸钠溶液质量分数为0.25%、海藻酸钠与壳聚糖的质量比为1：1.当壳聚糖溶液pH = 5.0时，复合膜的药物控释性能最强.通过Ca2+的交联，使替硝唑的包埋率达到96.1%.复合膜的溶胀度研究表明，在pH = 11的介质中具有最大的溶胀度.https://doi.org/zjup/1008-9497.2006.33.4.444-446替硝唑壳聚糖海藻酸钠药物控制释放 |
| spellingShingle | LINXian-zhen(林咸真) ZHENGHao(郑豪) ZHUKe-long(朱克龙) Study on release characteristics of tinidazole-chitosan-sodium alginate complex membrane(替硝唑-壳聚糖-海藻酸钠生物复合膜的缓释性能研究) Zhejiang Daxue xuebao. Lixue ban 替硝唑 壳聚糖 海藻酸钠 药物控制释放 |
| title | Study on release characteristics of tinidazole-chitosan-sodium alginate complex membrane(替硝唑-壳聚糖-海藻酸钠生物复合膜的缓释性能研究) |
| title_full | Study on release characteristics of tinidazole-chitosan-sodium alginate complex membrane(替硝唑-壳聚糖-海藻酸钠生物复合膜的缓释性能研究) |
| title_fullStr | Study on release characteristics of tinidazole-chitosan-sodium alginate complex membrane(替硝唑-壳聚糖-海藻酸钠生物复合膜的缓释性能研究) |
| title_full_unstemmed | Study on release characteristics of tinidazole-chitosan-sodium alginate complex membrane(替硝唑-壳聚糖-海藻酸钠生物复合膜的缓释性能研究) |
| title_short | Study on release characteristics of tinidazole-chitosan-sodium alginate complex membrane(替硝唑-壳聚糖-海藻酸钠生物复合膜的缓释性能研究) |
| title_sort | study on release characteristics of tinidazole chitosan sodium alginate complex membrane 替硝唑 壳聚糖 海藻酸钠生物复合膜的缓释性能研究 |
| topic | 替硝唑 壳聚糖 海藻酸钠 药物控制释放 |
| url | https://doi.org/zjup/1008-9497.2006.33.4.444-446 |
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