Mechanism of action of sprG1-encoded type I toxins in Staphylococcus aureus: from membrane alterations to mesosome-like structures formation and bacterial lysis

Mechanism of action of sprG1-encoded type I toxins in Staphylococcus aureus: from membrane alterations to mesosome-like structures formation and bacterial lysis

sprG1/SprF1 is a type I toxin-antitoxin system located on Staphylococcus aureus prophage. It has previously been shown that the two toxins, SprG131 and SprG144, encoded by the sprG1 gene, are two membrane-associated peptides structured in a single α-helix. Overexpression of these two peptides leads...

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Bibliographic Details
Main Authors: Laurence Fermon, Agnès Burel, Emeline Ostyn, Stéphane Dréano, Arnaud Bondon, Soizic Chevance, Marie-Laure Pinel-Marie
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Microbiology
Subjects:
type l toxin-antitoxin systems
Staphylococcus aureus
membrane depolarization
ATP depletion
membrane permeabilization
mesosome-like structures
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1275849/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2023.1275849/full

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