Vitamin D Status and Predictors of Hypovitaminosis D in Internationally Adopted Children.
To evaluate vitamin D status in internationally adopted children at first medical evaluation in Italy and to identify possible risk factors for hypovitaminosis D in this population.25-hydroxyvitamin D [25(OH)D] levels were analyzed in internationally adopted children consecutively recruited at one I...
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| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5042493?pdf=render |
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| author | Elena Chiappini Francesco Vierucci Francesca Ghetti Maurizio de Martino Luisa Galli |
| author_facet | Elena Chiappini Francesco Vierucci Francesca Ghetti Maurizio de Martino Luisa Galli |
| author_sort | Elena Chiappini |
| collection | DOAJ |
| description | To evaluate vitamin D status in internationally adopted children at first medical evaluation in Italy and to identify possible risk factors for hypovitaminosis D in this population.25-hydroxyvitamin D [25(OH)D] levels were analyzed in internationally adopted children consecutively recruited at one Italian Center between 2010 and 2014 as part of the first screening protocol. Demographic, clinical and laboratory data were prospectively collected. Serum 25(OH)D levels <10 ng/mL, <20 ng/mL, and <30 ng/mL were used to define severe vitamin D deficiency, vitamin D deficiency and hypovitaminosis D, respectively.962 internationally adopted children (median age: 5.47 years; IQR:3.14-7.93) were included in the study. Median 25(OH)D level was 22.0 ng/mL (IQR:15.0-30.0 ng/mL); 710/962 (73.8%) children showed hypovitaminosis D (<30 ng/mL), 388/962 (40.3%) had vitamin D deficiency (<20 ng/dL), and 92/962 (9.6%) had severe vitamin D deficiency (<10ng/mL). No case of clinical rickets was observed. Hypovitaminosis D was particularly frequent (>90%) in children adopted from Ethiopia, Peru, India, Bulgaria and Lithuania. At multivariate analysis an increased risk of hypovitaminosis D was found to be associated with: age ≥ 6 years, time spent in Italy ≥ 3 months, blood sample taken in winter, spring or fall, compared to summer. Gender, ethnicity/continent of origin, tubercular infection, intestinal parassitosis and BMI-z-score < -2 were not associated with vitamin D status.Hypovitaminosis D is common in internationally adopted children, from all ethnic group. The evaluation of serum 25(OH)D level could be useful early after the adoption to promptly start vitamin D supplementation/treatment if needed. |
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| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T01:38:33Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-f0c13a8526264884bd6df7150c3c74a22022-12-22T00:03:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01119e015846910.1371/journal.pone.0158469Vitamin D Status and Predictors of Hypovitaminosis D in Internationally Adopted Children.Elena ChiappiniFrancesco VierucciFrancesca GhettiMaurizio de MartinoLuisa GalliTo evaluate vitamin D status in internationally adopted children at first medical evaluation in Italy and to identify possible risk factors for hypovitaminosis D in this population.25-hydroxyvitamin D [25(OH)D] levels were analyzed in internationally adopted children consecutively recruited at one Italian Center between 2010 and 2014 as part of the first screening protocol. Demographic, clinical and laboratory data were prospectively collected. Serum 25(OH)D levels <10 ng/mL, <20 ng/mL, and <30 ng/mL were used to define severe vitamin D deficiency, vitamin D deficiency and hypovitaminosis D, respectively.962 internationally adopted children (median age: 5.47 years; IQR:3.14-7.93) were included in the study. Median 25(OH)D level was 22.0 ng/mL (IQR:15.0-30.0 ng/mL); 710/962 (73.8%) children showed hypovitaminosis D (<30 ng/mL), 388/962 (40.3%) had vitamin D deficiency (<20 ng/dL), and 92/962 (9.6%) had severe vitamin D deficiency (<10ng/mL). No case of clinical rickets was observed. Hypovitaminosis D was particularly frequent (>90%) in children adopted from Ethiopia, Peru, India, Bulgaria and Lithuania. At multivariate analysis an increased risk of hypovitaminosis D was found to be associated with: age ≥ 6 years, time spent in Italy ≥ 3 months, blood sample taken in winter, spring or fall, compared to summer. Gender, ethnicity/continent of origin, tubercular infection, intestinal parassitosis and BMI-z-score < -2 were not associated with vitamin D status.Hypovitaminosis D is common in internationally adopted children, from all ethnic group. The evaluation of serum 25(OH)D level could be useful early after the adoption to promptly start vitamin D supplementation/treatment if needed.http://europepmc.org/articles/PMC5042493?pdf=render |
| spellingShingle | Elena Chiappini Francesco Vierucci Francesca Ghetti Maurizio de Martino Luisa Galli Vitamin D Status and Predictors of Hypovitaminosis D in Internationally Adopted Children. PLoS ONE |
| title | Vitamin D Status and Predictors of Hypovitaminosis D in Internationally Adopted Children. |
| title_full | Vitamin D Status and Predictors of Hypovitaminosis D in Internationally Adopted Children. |
| title_fullStr | Vitamin D Status and Predictors of Hypovitaminosis D in Internationally Adopted Children. |
| title_full_unstemmed | Vitamin D Status and Predictors of Hypovitaminosis D in Internationally Adopted Children. |
| title_short | Vitamin D Status and Predictors of Hypovitaminosis D in Internationally Adopted Children. |
| title_sort | vitamin d status and predictors of hypovitaminosis d in internationally adopted children |
| url | http://europepmc.org/articles/PMC5042493?pdf=render |
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