Synthesis and Immunological Evaluation of Mannosylated Desmuramyl Dipeptides Modified by Lipophilic Triazole Substituents

Synthesis and Immunological Evaluation of Mannosylated Desmuramyl Dipeptides Modified by Lipophilic Triazole Substituents

Muramyl dipeptide (<i>N</i>-acetylmuramyl-L-alanyl-D-isoglutamine, MDP) is the smallest peptidoglycan fragment able to trigger an immune response by activating the NOD2 receptor. Structural modification of MDP can lead to analogues with improved immunostimulating properties. The aim of t...

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Bibliographic Details
Main Authors: Vesna Petrović Peroković, Željka Car, Mia Bušljeta, Danijela Mihelec, Marija Paurević, Siniša Ivanković, Ranko Stojković, Rosana Ribić
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
mannose
desmuramyl peptide
triazole
immunostimulating activity
Online Access:https://www.mdpi.com/1422-0067/23/15/8628

Internet

https://www.mdpi.com/1422-0067/23/15/8628

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