Activation of PAC1 receptors in rat cerebellar granule cells stimulates both calcium mobilization from intracellular stores and calcium influx through N-type calcium channels

Activation of PAC1 receptors in rat cerebellar granule cells stimulates both calcium mobilization from intracellular stores and calcium influx through N-type calcium channels

High concentrations of pituitary adenylate cyclase-activating polypeptide (PACAP) and a high density of PACAP binding sites have been detected in the developing rat cerebellum. In particular, PACAP receptors are actively expressed in immature granule cells, where they activate both adenylyl cyclase...

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Bibliographic Details
Main Authors: Magali eBasille-Dugay, Hubert eVaudry, Alain eFournier, Bruno J. Gonzalez, David eVaudry
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-05-01
Series:Frontiers in Endocrinology
Subjects:
Autoradiography
Calcium
Calcium Channels
Cerebellum
Pituitary Adenylate Cyclase-Activating Polypeptide
granule cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00056/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00056/full

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