Whole Exome Sequencing Reveals a Novel APOE Mutation in a Patient With Sporadic Early-Onset Alzheimer's Disease

Whole Exome Sequencing Reveals a Novel APOE Mutation in a Patient With Sporadic Early-Onset Alzheimer's Disease

Apolipoprotein (APOE) is implicated and verified as the main risk factor for early-onset Alzheimer's disease (AD). APOE is a protein that binds to lipids and is involved in cholesterol stability. Our paper reports a case of a sporadic early-onset AD (sEOAD) patient of a 54-year-old Korean man,...

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Bibliographic Details
Main Authors: Jaya Bagaria, Yeonsil Moon, Eva Bagyinszky, Kyu Hwan Shim, Seong Soo A. An, SangYun Kim, Seol Heui Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Neurology
Subjects:
Low-Density Lipoprotein Receptor (LDLR)
APOE
Leu159Pro
early-onset Alzheimer's disease
novel mutation
Whole Exome Sequence (WES) analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.899644/full

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https://www.frontiersin.org/articles/10.3389/fneur.2022.899644/full

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