Transcriptional Profiling of a Patient-Matched Cohort of Glioblastoma (IDH-Wildtype) for Therapeutic Target and Repurposing Drug Identification

Transcriptional Profiling of a Patient-Matched Cohort of Glioblastoma (IDH-Wildtype) for Therapeutic Target and Repurposing Drug Identification

Glioblastoma (GBM) is the most prevalent and aggressive adult brain tumor. Despite multi-modal therapies, GBM recurs, and patients have poor survival (~14 months). Resistance to therapy may originate from a subpopulation of tumor cells identified as glioma-stem cells (GSC), and new treatments are ur...

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Bibliographic Details
Main Authors: Aideen C. Roddy, Caitríona E. McInerney, Tom Flannery, Estelle G. Healy, James P. Stewart, Veronica J. Spence, Jamie Walsh, Manuel Salto-Tellez, Darragh G. McArt, Kevin M. Prise
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Biomedicines
Subjects:
brain tumor
recurrent glioblastoma
patient-matched samples
whole transcriptome profiling
Clariom<sup>TM</sup> D Human Assay
connectivity mapping
Online Access:https://www.mdpi.com/2227-9059/11/4/1219

Internet

https://www.mdpi.com/2227-9059/11/4/1219

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