Common Statin Intolerance Variants in ABCB1 and LILRB5 Show Synergistic Effects on Statin Response: An Observational Study Using Electronic Health Records

Common Statin Intolerance Variants in ABCB1 and LILRB5 Show Synergistic Effects on Statin Response: An Observational Study Using Electronic Health Records

Background: Statin intolerance impacts approximately 10% of statin users, with side effects ranging from mild myalgia to extreme intolerance resulting in myopathy and rhabdomyolysis. Statin intolerance results in poor adherence to therapy and can impact statin efficacy. Many genetic variants are ass...

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Bibliographic Details
Main Authors: Alaa’ Lutfi Melhem, Mehul Kumar Chourasia, Margherita Bigossi, Cyrielle Maroteau, Alasdair Taylor, Roberto Pola, Adem Y. Dawed, Aleksi Tornio, Colin N. A. Palmer, Moneeza K. Siddiqui
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Genetics
Subjects:
pharmacogenomics
non-HDL-cholesterol
ABCB1
LILRB5
statins
hyperlipidaemia
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.713181/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.713181/full

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