The Toxin-Antitoxin MazEF Drives <named-content content-type="genus-species">Staphylococcus aureus</named-content> Biofilm Formation, Antibiotic Tolerance, and Chronic Infection

The Toxin-Antitoxin MazEF Drives <named-content content-type="genus-species">Staphylococcus aureus</named-content> Biofilm Formation, Antibiotic Tolerance, and Chronic Infection

ABSTRACT Staphylococcus aureus is the major organism responsible for surgical implant infections. Antimicrobial treatment of these infections often fails, leading to expensive surgical intervention and increased risk of mortality to the patient. The challenge in treating these infections is associat...

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Bibliographic Details
Main Authors: Dongzhu Ma, Jonathan B. Mandell, Niles P. Donegan, Ambrose L. Cheung, Wanyan Ma, Scott Rothenberger, Robert M. Q. Shanks, Anthony R. Richardson, Kenneth L. Urish
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mBio
Subjects:
surgical infection
biofilm
MazF
Staphylococcus aureus
toxin-antitoxin (TA) systems
icaADBC
Online Access:https://journals.asm.org/doi/10.1128/mBio.01658-19

Internet

https://journals.asm.org/doi/10.1128/mBio.01658-19

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