PI3Kδ Inhibition Potentiates Glucocorticoids in B-lymphoblastic Leukemia by Decreasing Receptor Phosphorylation and Enhancing Gene Regulation

PI3Kδ Inhibition Potentiates Glucocorticoids in B-lymphoblastic Leukemia by Decreasing Receptor Phosphorylation and Enhancing Gene Regulation

Glucocorticoids are the cornerstone of B-lymphoblastic leukemia (B-ALL) therapy. Because response to glucocorticoids alone predicts overall outcomes for B-ALL, enhancing glucocorticoid potency should improve treatment. We previously showed that inhibition of the lymphoid-restricted PI3Kδ with idelal...

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Bibliographic Details
Main Authors: Jessica A. O. Zimmerman, Mimi Fang, Miles A. Pufall
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cancers
Subjects:
glucocorticoids
chemotherapy
drug resistance
neoplasia-lymphoid leukemias
pediatric hematology/oncology
Online Access:https://www.mdpi.com/2072-6694/16/1/143

Internet

https://www.mdpi.com/2072-6694/16/1/143

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