Novel Galectins Purified from the Sponge <i>Chondrilla australiensis</i>: Unique Structural Features and Cytotoxic Effects on Colorectal Cancer Cells Mediated by TF-Antigen Binding

Novel Galectins Purified from the Sponge <i>Chondrilla australiensis</i>: Unique Structural Features and Cytotoxic Effects on Colorectal Cancer Cells Mediated by TF-Antigen Binding

We here report the purification of a novel member of the galectin family, the β-galactoside-binding lectin hRTL, from the marine sponge <i>Chondrilla australiensis</i>. The hRTL lectin is a tetrameric proto-type galectin with a subunit molecular weight of 15.5 kDa, consisting of 141 amin...

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Bibliographic Details
Main Authors: Ryuhei Hayashi, Kenichi Kamata, Marco Gerdol, Yuki Fujii, Takashi Hayashi, Yuto Onoda, Nanae Kobayashi, Satoshi Furushima, Ryuya Ishiwata, Mayuka Ohkawa, Naoko Masuda, Yuka Niimi, Masao Yamada, Daisuke Adachi, Sarkar M. A. Kawsar, Sultana Rajia, Imtiaj Hasan, Somrita Padma, Bishnu Pada Chatterjee, Yuji Ise, Riku Chida, Kayo Hasehira, Nobumitsu Miyanishi, Tatsuya Kawasaki, Yukiko Ogawa, Hideaki Fujita, Alberto Pallavicini, Yasuhiro Ozeki
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Marine Drugs
Subjects:
<i>Chondrilla australiensis</i>
galectin
Porifera
TF-antigen
signal peptide
cytotoxicity
Online Access:https://www.mdpi.com/1660-3397/22/9/400

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https://www.mdpi.com/1660-3397/22/9/400

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