Optoacoustic imaging with an air-coupled transducer using coaxially aligned focused illumination
Optoacoustic (OA) methods have become powerful tools in biomedical research capable of retrieving functional information from biological tissues in vivo. Acquisition of OA signals generally relies on direct physical contact of a transducer or an acoustic coupling medium with the tissue surface, whic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2022-03-01
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| Series: | AIP Advances |
| Online Access: | http://dx.doi.org/10.1063/5.0078053 |
| _version_ | 1828257132244369408 |
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| author | Cagla Özsoy Jianuo Xu Jiao Li Francisco Montero de Espinosa Daniel Razansky Xosé Luís Deán-Ben |
| author_facet | Cagla Özsoy Jianuo Xu Jiao Li Francisco Montero de Espinosa Daniel Razansky Xosé Luís Deán-Ben |
| author_sort | Cagla Özsoy |
| collection | DOAJ |
| description | Optoacoustic (OA) methods have become powerful tools in biomedical research capable of retrieving functional information from biological tissues in vivo. Acquisition of OA signals generally relies on direct physical contact of a transducer or an acoustic coupling medium with the tissue surface, which prevents applicability, e.g., in open surgeries or wounded tissues. Non-contact OA imaging has been achieved with air-coupled piezoelectric transducers, which provide a straightforward approach for remote sensing of ultrasound vibrations. However, sensitivity was hampered by a suboptimal alignment between the illumination and detection fields. Herein, we devised an air-coupled transducer featuring a central aperture for light delivery with coaxially aligned optical and acoustic foci, thus providing optimal sensitivity for OA signal detection. Imaging of phantoms and a mouse ear in vivo is showcased by raster-scanning the transducer with light being delivered through a multimode optical fiber. |
| first_indexed | 2024-04-13T02:37:11Z |
| format | Article |
| id | doaj.art-f0db1da6c6d047d5b064743eb7b7b090 |
| institution | Directory Open Access Journal |
| issn | 2158-3226 |
| language | English |
| last_indexed | 2024-04-13T02:37:11Z |
| publishDate | 2022-03-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | AIP Advances |
| spelling | doaj.art-f0db1da6c6d047d5b064743eb7b7b0902022-12-22T03:06:20ZengAIP Publishing LLCAIP Advances2158-32262022-03-01123035043035043-510.1063/5.0078053Optoacoustic imaging with an air-coupled transducer using coaxially aligned focused illuminationCagla Özsoy0Jianuo Xu1Jiao Li2Francisco Montero de Espinosa3Daniel Razansky4Xosé Luís Deán-Ben5Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zürich, 8057 Zürich, SwitzerlandSchool of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, ChinaSchool of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, ChinaCSIC, Institute of Physics and Communication Technologies, Madrid, SpainInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zürich, 8057 Zürich, SwitzerlandInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zürich, 8057 Zürich, SwitzerlandOptoacoustic (OA) methods have become powerful tools in biomedical research capable of retrieving functional information from biological tissues in vivo. Acquisition of OA signals generally relies on direct physical contact of a transducer or an acoustic coupling medium with the tissue surface, which prevents applicability, e.g., in open surgeries or wounded tissues. Non-contact OA imaging has been achieved with air-coupled piezoelectric transducers, which provide a straightforward approach for remote sensing of ultrasound vibrations. However, sensitivity was hampered by a suboptimal alignment between the illumination and detection fields. Herein, we devised an air-coupled transducer featuring a central aperture for light delivery with coaxially aligned optical and acoustic foci, thus providing optimal sensitivity for OA signal detection. Imaging of phantoms and a mouse ear in vivo is showcased by raster-scanning the transducer with light being delivered through a multimode optical fiber.http://dx.doi.org/10.1063/5.0078053 |
| spellingShingle | Cagla Özsoy Jianuo Xu Jiao Li Francisco Montero de Espinosa Daniel Razansky Xosé Luís Deán-Ben Optoacoustic imaging with an air-coupled transducer using coaxially aligned focused illumination AIP Advances |
| title | Optoacoustic imaging with an air-coupled transducer using coaxially aligned focused illumination |
| title_full | Optoacoustic imaging with an air-coupled transducer using coaxially aligned focused illumination |
| title_fullStr | Optoacoustic imaging with an air-coupled transducer using coaxially aligned focused illumination |
| title_full_unstemmed | Optoacoustic imaging with an air-coupled transducer using coaxially aligned focused illumination |
| title_short | Optoacoustic imaging with an air-coupled transducer using coaxially aligned focused illumination |
| title_sort | optoacoustic imaging with an air coupled transducer using coaxially aligned focused illumination |
| url | http://dx.doi.org/10.1063/5.0078053 |
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