Synthesis and Anticancer Activity of Mitotic-Specific 3,4-Dihydropyridine-2(1<i>H</i>)-thiones

Synthesis and Anticancer Activity of Mitotic-Specific 3,4-Dihydropyridine-2(1<i>H</i>)-thiones

Most anticancer drugs target mitosis as the most crucial and fragile period of rapidly dividing cancer cells. However the limitations of classical chemotherapeutics drive the search for new more effective and selective compounds. For this purpose structural modifications of the previously characteri...

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Bibliographic Details
Main Authors: Magdalena Perużyńska, Aleksandra Borzyszkowska-Ledwig, Jacek G. Sośnicki, Łukasz Struk, Tomasz J. Idzik, Gabriela Maciejewska, Łukasz Skalski, Katarzyna Piotrowska, Paweł Łukasik, Marek Droździk, Mateusz Kurzawski
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
dihydropyridine
mitotic spindle
tubulin inhibitors
colchicine-binding site
anticancer agents
Online Access:https://www.mdpi.com/1422-0067/22/5/2462

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https://www.mdpi.com/1422-0067/22/5/2462

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