Characterization of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells

Characterization of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells

ObjectiveEndoC-βH5 is a newly established human beta-cell model which may be superior to previous model systems. Exposure of beta cells to pro-inflammatory cytokines is widely used when studying immune-mediated beta-cell failure in type 1 diabetes. We therefore performed an in-depth characterization...

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Bibliographic Details
Main Authors: Caroline Frørup, Rebekka Gerwig, Cecilie Amalie Søndergaard Svane, Joana Mendes Lopes de Melo, Kristine Henriksen, Tina Fløyel, Flemming Pociot, Simranjeet Kaur, Joachim Størling
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Endocrinology
Subjects:
pancreatic beta cells
type 1 diabetes
model system
inflammation
apoptosis
insulin
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1128523/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1128523/full

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