Hybrid chalcogen bonds in prodrug nanoassemblies provides dual redox-responsivity in the tumor microenvironment

Hybrid chalcogen bonds in prodrug nanoassemblies provides dual redox-responsivity in the tumor microenvironment

While homodimeric prodrug assemblies can improve drug loading and limit toxicity in cancer therapy, bioactivation within the target site is limited. Here, the authors introduce a hybrid chalcogen bond linker to a docetaxel dimeric prodrug nanoassembly and demonstrate its improved selfassembly, redox...

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Bibliographic Details
Main Authors: Tian Liu, Lingxiao Li, Shuo Wang, Fudan Dong, Shiyi Zuo, Jiaxuan Song, Xin Wang, Qi Lu, Helin Wang, Haotian Zhang, Maosheng Cheng, Xiaohong Liu, Zhonggui He, Bingjun Sun, Jin Sun
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35033-7

Internet

https://doi.org/10.1038/s41467-022-35033-7

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