Hybrid chalcogen bonds in prodrug nanoassemblies provides dual redox-responsivity in the tumor microenvironment
While homodimeric prodrug assemblies can improve drug loading and limit toxicity in cancer therapy, bioactivation within the target site is limited. Here, the authors introduce a hybrid chalcogen bond linker to a docetaxel dimeric prodrug nanoassembly and demonstrate its improved selfassembly, redox...
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Bibliographic Details
Main Authors: |
Tian Liu,
Lingxiao Li,
Shuo Wang,
Fudan Dong,
Shiyi Zuo,
Jiaxuan Song,
Xin Wang,
Qi Lu,
Helin Wang,
Haotian Zhang,
Maosheng Cheng,
Xiaohong Liu,
Zhonggui He,
Bingjun Sun,
Jin Sun |
Format: | Article
|
Language: | English |
Published: |
Nature Portfolio
2022-11-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-022-35033-7
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