Case report: Novel NIPBL-BEND2 fusion gene identified in osteoblastoma-like phosphaturic mesenchymal tumor of the fibula

Case report: Novel NIPBL-BEND2 fusion gene identified in osteoblastoma-like phosphaturic mesenchymal tumor of the fibula

Phosphaturic mesenchymal tumor (PMT) is a rare tumor that secretes fibroblast growth factor 23 (FGF23) and causes hypophosphatemia and tumor-induced osteomalacia (TIO). Fusion genes FN1-FGFR1 and FN1-FGF1 have been detected in some PMTs, but the pathogenesis of PMTs without these fusion genes remain...

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Bibliographic Details
Main Authors: Tomohisa Sakai, Yusuke Okuno, Norihiro Murakami, Yoshie Shimoyama, Shiro Imagama, Yoshihiro Nishida
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
phosphaturic mesenchymal tumor
tumor induced osteomalacia
bone tumor
RNA sequencing
fusion gene
whole exome sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.956472/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.956472/full

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