Determination of the Protein-Protein Interactions within Acyl Carrier Protein (MmcB)-Dependent Modifications in the Biosynthesis of Mitomycin

Determination of the Protein-Protein Interactions within Acyl Carrier Protein (MmcB)-Dependent Modifications in the Biosynthesis of Mitomycin

Mitomycin has a unique chemical structure and contains densely assembled functionalities with extraordinary antitumor activity. The previously proposed mitomycin C biosynthetic pathway has caused great attention to decipher the enzymatic mechanisms for assembling the pharmaceutically unprecedented c...

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Bibliographic Details
Main Authors: Dongjin Leng, Yong Sheng, Hengyu Wang, Jianhua Wei, Yixin Ou, Zixin Deng, Linquan Bai, Qianjin Kang
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
mitomycin
antitumor
acyl carrier protein
protein–protein interactions
glycosyltransferase
reductase
Online Access:https://www.mdpi.com/1420-3049/26/22/6791

Internet

https://www.mdpi.com/1420-3049/26/22/6791

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